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In AD, the deposition of A can damage neuronal mitochondria through multiple pathways, leading to mitochondrial dysfunction (Gtz et al., 2011
This is measurable through blood markers
To confirm this, the expression of important proteins involved in redox homeostasis, including the NRF2/KEAP1 complex, SODs, and glutathione peroxidase (GPX) enzymes families in both macrophages and RANKL-stimulated BMMs was analyzed by WB
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