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Orally, however, bupropion is thought to have minimal abuse liability at recommended therapeutic doses

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These receptors are found in the hypothalamus

Combining both agents could theoretically amplify appetite suppression and gastrointestinal effects, though long-term safety data on this specific combination is lacking

Slower digestion means more time for gut bacteria to ferment food, which can produce gas, and more time for the colon to reabsorb water, which can make stool harder to pass

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