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In Freddd's protocol, supplements are started at very low doses and titrated, or increased until no effect is noted

Intestinal inflammation, dysbiosis, or increased permeability can significantly reduce DAO production and allow dietary histamine to enter circulation unchecked

Studies have examined its activity in musculoskeletal tissue models including tendon, ligament, and bone repair research, as well as gastrointestinal cytoprotection and neurological models

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