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Overexpression of the related protein GS2-Like in HEK 293 cells also results in decreased TAG storage, which suggests a functional role for both of these proteins in lipolysis in vivo (62)
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In septic lung injury, elevated lactate levels exacerbate alveolar epithelial cell ferroptosis through lactylated histone H3 lysine 18 (H3K18la)-mediated upregulation of METTL3, which enhances m6A modification of ACSL4, ultimately contributing to the development of acute respiratory distress syndrome (82)
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