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(CNN) The diabetes and weight loss drug semaglutide significantly reduced symptoms and improved quality of life in people with obesity and the most common form of heart failure in a clinical trial, potentially expanding the already wildly popular drugs use beyond diabetes and weight loss and offering a new treatment option where few are available

In preclinical studies, compounds such as VX-765 and pralnacasan have demonstrated efficacy in inhibiting caspase-1 activation and protecting against inflammatory diseases

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Weight maintenance after semaglutide therapy requires more than medication alone