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Its activity is studied through copper transport and signaling interactions rather than one receptor

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It is not affected by cyclicity and can reflect the declining trend of ovarian reserve earlier than other traditional biological indicators, like follicle-stimulating hormone, oestradiol and progesterone, which makes it to the first choice for evaluating ovarian reserve ( p = 0.793)

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The Pro-KIV 1.01 software (Applied Photophysics) was used to perform kinetic simulations of the mechanistic models using the determined rate constants from Table 1 based on the indicated reaction schemes

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