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Like many of us, you probably hadn't heard of GLP-1 until recently

Could probiotics enhance a GLP-1 medication

Effects of glucagon-like peptide-1 receptor agonists on major cardiovascular events in patients with type 2 diabetes mellitus with or without established cardiovascular disease: a meta-analysis of randomized controlled trials

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When comparing data from rodents with humans, results regarding GLP-1s renal effects are very different

For example, studies using radiolabeled exenatide have shown that it can readily enter the mouse brain, though this central uptake appears to diminish at higher doses (Kastin and Akerstrom, 2003)