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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Ni XP, Butler AA, Cone RD, Humphreys MH

A pooled analysis of 5 randomized placebo-controlled trials demonstrated a significant 13% reduction in the risk of total stroke with GLP-1 RAs compared with placebo, without significant heterogeneity between trials

Ice crystal formation during freezing physically shears peptide chains

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Mechanistically, erucic acid orchestrates this inhibition by impeding STAT3 phosphorylation and promoting ferroptosis

It is an energy-dependent process characterized by cell shrinkage, cytoskeletal disruption, membrane blebbing, chromatin condensation, nuclear and DNA fragmentation