These include uterine overdistension, ischemia, infection, cervical disease, endocrine disorders [237], decidual hemorrhage, and maternal-fetal activation of the hypothalamic-pituitary axis, amongst others [239]
GLP-1 receptor agonists such as semaglutide and tirzepatide have changed weight management by offering sustained results when used continuously
17 SorensenK.ICuric-BawdenM.JungeM
W.Jr.et al (2024)
It is believed to work through multiple pathways, including: Blocking voltage-gated sodium channels , reducing neuronal excitability Enhancing GABA (gamma-aminobutyric acid) activity , an inhibitory neurotransmitter Antagonising glutamate receptors , further dampening excitatory neurotransmission Inhibiting carbonic anhydrase enzymes , though the clinical significance of this effect is uncertain While topiramate's primary indications are epilepsy and migraine prophylaxis, it has been observed to cause weight loss as a side effect, likely through appetite suppression and altered taste perception
It flags this particularly for patients with underlying hypertension or cardiac conditions
