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NACP/alph-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains

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The split dosing approach maintains more consistent NNMT inhibition throughout the day, potentially enhancing metabolic benefits

I think that once Mounjaro is approved for weight loss at the end of 2023 this trend will gain steam in a significant way, which would likely reflect in Q2-Q3 2024 earnings for PHG, RMD etc

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50mg produces approximately 4050% enzyme inhibition, while 100mg achieves 6075% inhibition, but the curve plateaus beyond 150mg, suggesting diminishing returns