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Regarding the progression from NAFLD to NASH, liver fibrosis, cirrhosis, and ultimately HCC, different stages of the disease may involve distinct RCD mechanisms in different cell populations, which implies that treatment strategies at each stage may vary

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In summary, this dual mechanism addresses the fundamental lipid dysregulation in MASLD by restoring the balance between lipid synthesis and degradation within the liver, thereby mitigating steatosis and its metabolic consequences (40, 43)

Plaintiffs request a court order declaring the proclamation invalid and directing the EPA to enforce compliance deadlines in the 2024 rule