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References (1) Sivyer GW

Studies have indicated that, in human NAFLD patients, increased PARP activity could potentially lead to NAD + depletion and mitochondrial dysfunction 164

Katlinskaya YV, Katlinski KV, Yu Q, Ortiz A, Beiting DP, Brice A et al

It has also been shown to inhibit CTLA4 trafficking to the cell surface, which may result in lower protein expression in nave T cells and Tregs (90, 91)