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Since NSP activity is the core pharmacodynamic indicator for evaluating DPP1 inhibition effects, developing simple and accurate NSP activity detection methods is crucial for clinical research and individualized treatment ( 9.2 Future research directions Development and validation of biomarkers constitutes a key element for achieving precision treatment

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Only one 1 H-MRS metric was associated with illness severity: Glx/Creatine in the MTL, was mildly positively correlated with total symptom severity (estimate, 0.06) and this was mostly accounted by an effect of negative symptoms

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