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However, metformin is frequently prescribed off-label for prediabetes and can improve insulin sensitivity and lower blood sugar levels in people with prediabetes

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First, the lower levels of active incretin compared to healthy subjects due to the increased degradation by dipeptidyl peptidase-4 and reduced incretin production in patients with NAFLD may explain the beneficial effect of GLP-1RA in NAFLD treatment [44]

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F., Neto, J