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doi: 10.3389/fendo.2018.00035 Received 24 July 2017 Accepted 29 January 2018 Published 13 February 2018 Volume 9 - 2018 Edited by Stefan N

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As has also been the case with the TP53 gene mutation, inhibition of the protective action of the TP53 gene is observed due to the prevalence of missense mutations in cancer cells