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Co-treatment of cells with pitavastatin and the EGFR TKI erlotinib resulted in synergistically enhanced cytotoxicity when compared to pitavastatin monotherapy overcoming erlotinib resistance in K-ras mutated NSCLC and relying only on apoptosis [101]

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The receptor target is the same, yet the presentation, regulatory pathway, and availability differ

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Bellon JM, Filipe G

Gut microbiota dysbiosis negatively affects the regulation of anti-inflammatory and immune system responses and appears to be associated with autoimmune diseases, inflammation, and some types of cancer (189, 236, 237)