Some patients have exercise intolerance but little evidence of fluid retention, whereas others complain primarily of edema, dyspnea, or fatigue
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Meaningful weight reduction is generally observed by weeks 12 to 16, with maximum weight loss tending to occur later in the treatment period, depending on the agent and dose
Peptide tyrosine-tyrosine may also exert its actions via the vagus nerve which also expresses the Y2 receptor [13]
85 US National Institutes of Health