One model for how these drugs could be used in addiction medicine would be to have a person take these drugs, say, in the first you know, six months or a year of recovery to help knock down the cravings and also give them time to utilize other resources. Its a question that worries Stainbrook
Boruchow said
In support to this notion, we have shown: (i) L-cysteine, an activator of H 2 S producing enzymes (CSE and CBS), or the exogenous H 2 S donors NaHS and GYY4137 inhibited OA-induced GLP-1 and PYY release, and (ii) inhibition of release is due to suppression of the Epac/PLC-/Ca 2+ pathway downstream of cAMP pathway
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Scientific References Jastreboff, A.M., et al
Following regulatory approval, financial considerations will become paramount for patient access