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doi: 10.3945/an.115.009639 38 VanekovZRollingerJM

Hormonal systems interact extensively, and baseline imbalances may unpredictably affect response to peptide administration

Mar 16 2021;325(11):1061-1073

Functional and phenotypic analyses confirm the induction of a pancreatic endocrine fate, including positive dithizone (DTZ) staining indicative of insulin production, as well as the upregulation of key pancreatic markers such as Nestin , PDX-1 , paired box gene 4 ( PAX4 ), neurogenin 3 ( NGN3 ), Isl-1, MAFA, insulin, and glucose transporter 2 ( GLUT2 )