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Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, et al

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Metabolites produced by the gut microbiota serve as key mediators between the microbiota and the host, interacting with multiple systems in the body to regulate physiological and pathological functions

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One mechanism is telomerase activation, particularly through increased expression of the catalytic subunit hTERT