There was an early differentiation in the incidence of OSA (from the first 12 months of the study) between patients treated with ERTU versus placebo
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Arvat E, Di Vito L, Broglio F, et al
To avoid this pitfall, we here use PAR2-mutant mice (PAR2-G37I and PAR2-R38E) that retain activation-independent signaling receptor platforms involving PAR2, while abolishing cleavage sensitivity to specific proteases (21, 22, 30, 31)
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