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Topical is the more evidence-supported route, especially for skin endpoints

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Spiking blood simultaneously with extraction buffer (Sample Type 2) resulted in improved recoveries98% for NAD + , 85% for NADH (with only 10% converting to NAD + ), 95% for NADP + and 82% for NADPH

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Clinical Relevance: These findings explain GHK-Cu's accelerated wound closure observed in clinical settings and its interest as a therapeutic candidate for chronic wounds, post-surgical recovery, and tissue regeneration applications

doi:10.1021/cr500131f