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L-Carnitine improves gastrointestinal disorders and altered the intestinal microbiota in hemodialysis patients

Vitamin C is essential for the biosynthesis of carnitine

Li Y, Miao LY, Xiao YL, Huang M, Yu M, Meng K, et al

The anti-inflammatory effects protect blood vessel walls from the chronic inflammation that drives atherosclerosis

Additional considerations include diabetic retinopathy status (semaglutide may worsen retinopathy in some patients with pre-existing disease, particularly with rapid A1c improvement), history of pancreatitis (use GLP-1 agents with caution), and upcoming surgical procedures (discuss with your surgical/anesthesia team due to effects on gastric emptying)