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Clinical trials have demonstrated a reduced risk of major adverse cardiovascular events, such as heart attack and stroke, in individuals treated with semaglutide

At GIPR, it enhances the incretin effect and modulates adipose lipid metabolism

This could lead to lower food intake and weight loss

Appetite may feel normal or slightly reduced

The activity of MC4R is strictly regulated by its endogenous ligands: -melanocyte-stimulating hormone (-MSH) binds to MC4R and transmits anorexigenic and energy-expenditure signals, whereas agouti-related protein (AgRP) exerts an antagonistic effect by binding to the receptor, competitively inhibiting -MSH action and promoting appetite

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