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Many studies have been done to prove that hydroxocobalamin is a better form of vitamin B12, however, due to increased cost it is not used as often

Patients frequently experience difficulties in accessing specialized medical care in adulthood, resulting in loss to follow-up affecting the patients physical and psychological health as well as quality of life

It should be noted that these studies measured total Cbl levels, but as previously mentioned, the biologically available form of Cbl, TCN2-Cbl, comprises only approximately 2030% of the total Cbl level, which may lead to a significant number of false negatives for clb deficiency

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