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The evidence from published intervention trials is consistent: T/T individuals receiving adequate 5-MTHF + B12 + B6 supplementation normalize plasma homocysteine to levels similar to C/C individuals, restore BH4 availability and endothelial function, and reduce the functional consequences of MTHFR impairment across most of the five longevity mechanisms described above

Male patients, conversely, showed more pronounced peroxisome dysfunction and severe mitochondrial lipid oxidative damage

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The authors acknowledge the support of the Open Access Publication Fund of the University of Duisburg-Essen

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