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The GLP-1R are expressed in tissues other than pancreatic islets 24 , as in hepatocytes, but studies suggest that certain actions of GLP-1 in hepatic glucose metabolism occur through mechanisms that are independent of GLP-1R, and no alternative route seems to have been fully elucidated 25

Starting at 2.5mg weekly, increasing to 5mg at week five, then 7.5mg, 10mg, 12.5mg, and 15mg at four-week intervals