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4 Future directions - utilizing 3D adipose tissue technologies for lipedema research As the lipedema field moves toward more comprehensive models, several 3D technologies from general adipose research offer high potential for lipedema applications

In contrast, ferroptosis has emerged as a key driver of ARDS pathogenesis, contributing to epithelial and endothelial cell injury, oxidative stress, and immune dysfunction

Even less is known regarding its potential role in tumour metastasis and the potential side effects of GSH catabolism in specific tissues (for example, release of glutamate in brain metastasis)

This age-related decline has attracted serious scientific interest

Collectively, these factors highlight the need for carefully designed therapies that can selectively target GSH in tumors while minimizing toxicity and overcoming adaptive resistance mechanisms