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A review and presentation of cases

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In preclinical models, direct activation of GLP-1Rs in the NTS reduces food and drug intake, whereas knockdown of GLP-1R in this region reverses these effects [20,35]

Immune regulation within the tumor microenvironment plays a critical role in tumor progression and chemotherapy resistance

Semaglutide is FDA-approved for both type 2 diabetes (Ozempic, 2017) and chronic weight management (Wegovy, 2021), with extensive Phase 3 clinical trial data including the STEP program and SELECT cardiovascular outcomes trial (PMID: 37952131)