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doi: 10.1021/pr500153m 109 Huerta-OcampoJ..N.Briones-CereceroE

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For example, GLP-1 (736) has been shown to inhibit cell death processes in cholangiocytes,15 neurons,16 and pancreatic beta cells.17,18 A combination of antiapoptotic and antinecrotic effects has been reported in pancreatic beta cells.19 Such a cytoprotection appears to be due to the direct preservation of mitochondria, as studies in hepatocytes show that GLP-1 (736) exerts insulin-like effects through the modulation of oxidative phosphorylation and the inhibition of oxidative stress.20 A wide variety of cardiovascular actions of GLP-1 have been reported to date, including hemodynamic system changes.21,22 Specifically, cytoprotective actions of GLP-1 (736) have been reported in the heart.2124 In this regard, the fact that different studies show the presence of GLP-1R in the myocardium of different animal models25,26 and in human cardiac tissue27 suggests that GLP-1 (736) may have direct effects on the heart