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Yes, B12 supplementation is appropriate if deficiency is confirmed, and the MHRA recommends monitoring B12 levels in people on long-term metformin
What is vitamin B12 and why does it matter
In esophageal injury models, BPC-157 normalizes sphincter function by increasing pressure in both the lower esophageal sphincter (LES) and pyloric sphincter (PS) in animals with sphincter dysfunction, while in healthy animals the peptide demonstrates adaptive effects that maintain physiological sphincter tone
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doi:10.2164/jandrol.110.011874
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