Similar content being viewed by others Introduction At the cellular level, cells represent the fundamental functional units of tissues, and their viability and functionality rely heavily on the maintenance of a stable intracellular homeostatic environment throughout tissue development and systemic physiological processes [1]
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Here, our genetic screening of the previously constructed hairpin RNA-based Arabidopsis library identifies a glutathione (GSH)-deficient mutant that has high accumulation of glutamate (Glu), a previously defined wound signal essential for activating plant defense, but disharmoniously exhibits attenuation of defense signaling events
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Silencing SAT1 significantly abrogates p53-mediated ferroptosis, while upregulation of SAT1 expression sensitizes cells to ferroptosis upon hypoxic conditions
