Interestingly, recent reports suggest that appendectomies lowered PD risk, while individuals with an intact vermiform appendix showed increased levels of truncated soluble -synuclein, capable of oligomerization and propagation (Killinger et al., 2018)
These findings suggest that NHPN-1010 could be a beneficial agent for the treatment of NIT through reversal of cochlear synapthopathy in the IHC area and suppression of neuronal hyperactivity in the CAS
A similar local delivery of GHK-Cu could be investigated in small clinical trials
doi:10.1093/brain/awh287 95. Pia, H., Ruzena, K., Andrzej, P., Abdonas, T., Ben, S., Hynek, P., Anne, P., Magdalena, K., Eufene, J., Archana, S.-M., & Martin, B
Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury
In lean subjects, NNMT activity in adipose tissue tends to be low