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Practical considerations: IV administration requires clinical supervision

Some considerations and risks of long-term use include metabolic effects that could be changes in insulin sensitivity and cardiovascular effects that could shift blood pressure or lipid levels in vulnerable individuals

Concurrent nutritional deficienciesparticularly folate or iron deficiencycan impair the response to B12 treatment, as these nutrients work together in red blood cell production

This method ensures maximum absorption, bypassing the digestive system for better results

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It must be administered by a trained OT and carried out multiple times per day