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One of the earliest recognized actions of incretin hormones is the enhancement of glucose-dependent insulin secretion, which accounts for greater insulin release and lower glycemic responses following oral compared to intravenous glucose administration (Mller et al., 2019)

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The peptide binds copper with extraordinarily high affinity (pK = 16.44), which is roughly 10 million times higher than other tripeptides and comparable to albumins copper binding

Arch Intern Med 142:2281-2283, 1982

Top-line results from REDEFINE 1 have been reported by Novo Nordisk

the majority were studies on the prevalence of germline and/or somatic mutations