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One example is the dysregulation of GSH homeostasis and alterated levels or functions of GSTs (both decrease or increase) 48,49

A growing body of evidence suggests that reactive oxygen species (ROS) are implicated in OA pathogenesis by triggering oxidative stress 2,8,9

Lee, S., Abecasis, G

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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

She has walked every step of this journey with me, and Acupuncture Zen exists, in no small part, because of her steady presence beside me