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EORTC Melanoma Group sentinel node protocol identifies high rate of submicrometastases according to Rotterdam Criteria

Any new or worsening symptom, particularly severe abdominal pain, persistent vomiting, yellowing of the skin or eyes, or signs of allergic reaction, requires prompt medical attention

Liu H, Huang H, Li B, Wu D, Wang F, Zheng X, et al

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Esophageal tears or perforations may lead to pneumothorax or pneumomediastinum

It will still have to go through Phase 3 clinical trials before FDA approval