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The only benefit may be the possibility of pyruvate decarboxylation by the pyruvate dehydrogenase complex (PDC) [96], which produces the equimolar amount of NADH

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This non-canonical role of Smad5 promotes the acidification of insulin secretory vesicles that ultimately promotes insulin processing and secretion

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However, the underlying cause of the deficiency must also be addressed in order to prevent relapse and further complications

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