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[DOI] [PubMed] [Google Scholar] 47.Rosenkranz M.A., Busse W.W., Johnstone T., Swenson C.A., Crisafi G.M., Jackson M.M., Bosch J.A., Sheridan J.F., Davidson R.J

Unblinding Unblinding of the participants will be permissible under the following circumstances: treatment of a participant in a medical emergency that requires knowledge of treatment allocation, treatment of a participant for an adverse event (AE), in the event of a suspected unexpected serious adverse reaction (SAR), and SAR is defined as any untoward medical occurrence that results in death, is life-threatening, requires hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity or is a congenital anomaly or birth defect

However, the cardiovascular outcome trials that have been completed so far have failed to show cardioprotection with DPP-4 inhibitor treatment, which might be partly attributable to limitations of the study design, patient selection and trial duration