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Subsequent research documented effects on elastin, glycosaminoglycans, fibronectin, and controlled matrix degradation a balance critical for normal tissue remodelling Gene expression modulation Genome-wide studies identified GHK-Cu-induced changes in expression of over 4,000 human genes (~32% of those assayed), including upregulation of tissue repair genes and downregulation of inflammatory and cancer-progression genes Antioxidant enzyme research Studied for upregulation of SOD1 and catalase expression in cell culture, with the copper-delivering function of the complex potentially contributing independently to antioxidant enzyme activity AHK-Cu Research Profile Hair follicle biology AHK-Cu has generated particular research interest for dermal papilla cell proliferation, follicle survival signalling, and hair cycle regulation in in-vitro skin models