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Human germline mutations in glutarate metabolism highlight its fundamental biological role, with loss of function mutations in glutaryl-CoA dehydrogenase (GCDH) resulting in glutarate accumulation and glutaric aciduria type 1 (GA1)a rare autosomal disorder characterized by dystonia, developmental delay and often death in early childhood 10

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Researchers examine peptide-mediated signaling involving growth factor regulation, intracellular messenger systems, transcriptional activity, protein expression, and coordinated biochemical adaptation

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Additionally, side effects like nausea and vomiting can contribute to dehydration, making it crucial to maintain adequate fluid intake

These are long-term medications to treat a chronic disease, said Dr