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We examined the effects of d-allulose on feeding behavior including arrhythmic hyperphagia that is characteristically associated with obesity and diabetes 3,4 and on glucose metabolism by glucose tolerance test (GTT), insulin tolerance test (ITT), and pyruvate tolerance test (PTT), and explored underlying mechanisms involving GLP-1 release and vagal afferents using Glp1r knockout mice ( Glp1r KO), surgical vagotomy and Glp1r knockdown specifically in vagal afferents using viral-mediated shRNA

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J Pathol (2019) 247(5):53951

Studies indicate that patients who tolerate initial dosing well maintain treatment longer, supporting cumulative weight loss over 12 to 24 months

Paul Conlin, who also serves as the chief of medical service for the VA Boston health care system