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The strongest human data on GHK-Cu is almost entirely topical, 12-week trials on photoaged skin, wrinkle-volume studies, and gene-expression work going back to Pickarts original research in the 1970s

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Look for active, co-enzymated, or methylated forms (e.g., riboflavin5phosphate, methylfolate, methylcobalamin) if you have trouble converting standard forms (such as MTHFR carriers) or if you suffer from functional deficiencies (i.e., B12-related anemia despite high serum levels of B12)

Shahmiri M, Enciso M, Adda CG, Smith BJ, Perugini MA, Mechler A

Phase 1 oral trial, and a small retrospective knee-pain case series without blinding