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To address this challenge, we previously developed a pathway network-based approach that identifies shared molecular pathways and potential therapeutic targets for comorbidities through the reconstruction and analysis of Disease-Disease pathway-pathway comorbidity networks 19

#cardiogen Figure 2 from this recent genetic cardiomyopathy paper is wild Patients with type 2 diabetes who carry a pathogenic cardiomyopathy variant had a 16% rate of heart failure hospitalization at 4 years on placebo, approx 5 higher than noncarriers

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