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As far as is known, the beneficial effect on the periphery suggests a corresponding beneficial effect on central systems
The restorative effect in damaged diabetic nerves versus the irritative effect in healthy nerves reconciles the improve-neuropathy / cause-dysesthesia split
Several studies have confirmed that GHR knock-out resulted in a delay in puberty onset, and this echoes the delayed puberty that is observed in human disorders such as Laron dwarfism where GHR is dysfunctional (25, 26)
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