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TEER values were measured every 24 h to confirm ensure the integrity and tightness of the BBB model

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It reversed glucose dysregulation without detrimental effects on metabolically healthy animals and reduced body weight, lowered fasting blood glucose, decreased glycosylated hemoglobin (HbA1C), improved glucose tolerance, and protected pancreatic islet architecture in diabetic fatty Zucker rats 22,23,24

38 Arginine regulates the active state of the urea cycle by acting as an allosteric activator of N-acetyl glutamate synthetase (a mitochondrial enzyme that converts glutamate and acetyl CoA to N-acetyl glutamate)

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