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however, this benefit needs more research

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This risk is based on observations in rodent studies, but a causal relationship in humans has not been established

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Metformin significantly inhibited OCR by 47% ( Figure 6A ) and ECAR by 36% ( Figure 6B ) in rectal adenocarcinoma biopsies, when compared to baseline, demonstrating metformin-induced modulation of energy metabolism in rectal tumours from patients