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VEGF-mediated disruption of endothelial CLN-5 promotes bloodbrain barrier breakdown

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In full-term neonates, its PK profile is characterized by low clearance (0.651 L/h/kg) and a relatively large volume of distribution (4.7 L/kg), resulting in prolonged and variable exposure, particularly in preterm infants (70, 93)

10.1053/j.gastro.2023.05.050 68 WangF.ZhangS.LuoQ.XieQ.XuH.DengG

The mechanisms align with the actual physiological demand: endurance is mitochondrial and tendon-driven, strength is connective-tissue and GH-axis-driven

EGCG is known to enhance thermogenesis and fat oxidation, further contributing to effective weight management and improved exercise performance