Needs confirmation in phase 3 trials before routine use
Discussion In this cohort study of patients with advanced DKD, we evaluated the associations between cardiovascular and kidney outcomes in patients with GLP-1RAs versus DPP-4is
Patients achieved substantial weight loss during the initial GLP-1 RA phase (~1822% at 12 months), which was subsequently maintained after its discontinuation, with total weight reduction reaching 25.5% (95% CI 23.127.9%) at 593 days, with most patients on metformin
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The rapid transit bypasses the normal gastric reservoir function, creating a 'nutrient bolus' effect that triggers excessive incretin secretion