If you suspect you're experiencing side effects from GLP-1 receptor agonists, report them to your healthcare provider and consider using the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk) to help monitor medication safety

When to seek immediate medical attention: Severe abdominal pain that doesn't resolve, possibly radiating to the back (potential pancreatitis) Persistent nausea and vomiting preventing adequate fluid intake (dehydration risk) Signs of allergic reaction: difficulty breathing, swelling of face or throat, severe rash Symptoms of thyroid tumors: lump in neck, hoarseness, difficulty swallowing (rare but serious) Severe hypoglycemia symptoms when used with insulin or sulfonylureas: confusion, seizures, loss of consciousness Changes in vision or eye pain (potential diabetic retinopathy complications, particularly with rapid improvement in blood glucose) Signs of kidney problems: decreased urination, swelling in legs or feet, unusual fatigue Symptoms of gallbladder problems: pain in right or middle upper abdomen, fever, yellowing of skin/eyes These medications carry a boxed warning regarding the risk of thyroid C-cell tumors, based on animal studies

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Most patients report decreased hunger and earlier satiety within the first one to two weeks of starting GLP-1 therapy
A rise in resting or baseline heart rate, though changes vary by age and medication
Each delivery suddenly becomes much more important